Datasette Agent is a new conversational AI assistant that lets users query data stored in Datasette using natural language, with LLM-powered SQL generation and an extensible plugin architecture. The tool integrates with modern LLMs (Gemini, Claude, local models) for reliable tool calling and SQL generation, and includes plugins for charts and other functionality. This represents a practical fusion of data querying and LLM agents with immediate applicability for engineers working with databases and AI.